Semax

Semax is a synthetic heptapeptide analogue of the N-terminal fragment of adrenocorticotropic hormone ACTH(4-10), developed at the Institute of Molecular Genetics in Moscow. The sequence Met-Glu-His-Phe-Pro-Gly-Pro extends native ACTH(4-10) with a C-terminal Pro-Gly-Pro tripeptide that improves metabolic stability against carboxypeptidase degradation and may contribute additional biological properties, as Pro-Gly-Pro is an established bioactive tripeptide in leukocyte chemotaxis research. Molecular formula: C37H51N9O10S | Molecular weight: 813.93 g/mol | CAS: 80714-61-0 | Sequence: Met-Glu-His-Phe-Pro-Gly-Pro | Amino acids: 7 | Parent peptide: ACTH(4-10) | Purity: greater than or equal to 98% as verified by HPLC | Form: Lyophilised powder | Storage: -20°C desiccated Published laboratory research has examined Semax in the context of BDNF (brain-derived neurotrophic factor) mRNA and protein expression in hippocampal and cortical tissues — Manchenko et al. (Journal of Neurochemistry, 2012) reported effects on BDNF gene expression and methylation status in rat hippocampus. Additional published research has investigated dopaminergic signalling in striatal models, serotonergic pathway modulation, and neuroprotection in ischaemia research models via interactions with the nitric oxide system and inflammatory mediators. The Met residue at position 1 is susceptible to oxidation, which can reduce peptide activity. Store under inert atmosphere if possible and use freshly reconstituted solutions promptly. Reconstitute with bacteriostatic water and avoid repeated freeze-thaw cycles. Supplied as a lyophilised powder. Store at -20°C protected from light, moisture, and oxidising conditions. For laboratory and analytical research purposes only. Not for human or veterinary use.