ACE-031

ACE-031 is a soluble fusion protein consisting of the extracellular domain of activin receptor type IIB (ActRIIB) linked to the Fc region of human IgG1. It functions as a ligand trap, sequestering myostatin (GDF-8) and activin A — potent TGF-beta superfamily members that signal through endogenous ActRIIB to activate Smad2/3 transcription factors, suppress muscle protein synthesis genes, and upregulate muscle atrophy ubiquitin ligases Atrogin-1 and MuRF-1.

Molecular weight: approximately 60 kDa (fusion protein) | CAS: 1260284-89-4 | Target pathway: Myostatin and Activin A / ActRIIB / Smad2/3 | Purity: greater than or equal to 98% as verified by HPLC | Form: Lyophilised powder | Appearance: White to off-white lyophilised powder | Storage: -20°C desiccated

Unlike myostatin-specific monoclonal antibodies, ACE-031 traps multiple ActRIIB ligands simultaneously, providing comprehensive pathway inhibition for research settings requiring pan-ligand blockade rather than myostatin-specific effects. The Fc region also enables long half-life through FcRn-mediated recycling, similar to IgG antibodies. Published research by Attie et al. (Muscle and Nerve, 2013) and Zhou et al. (Cell, 2010) examined ActRIIB antagonism in muscle biology models including cachexia.

ACE-031 and IGF-1 LR3 are complementary research tools representing opposing regulatory axes: myostatin/ActRIIB/Smad2/3 drives muscle catabolism while IGF-1/IGF-1R/PI3K/Akt drives muscle anabolism. Using both in parallel allows characterisation of the anabolic/catabolic signalling balance in muscle cell research. Also relevant alongside Tesamorelin and CJC-1295 for GH-IGF-1 axis comparisons.

Supplied as a lyophilised powder. Reconstitute with bacteriostatic water. Store at -20°C protected from light and moisture. For laboratory and analytical research purposes only. Not for human or veterinary use.