CJC-1295 (With DAC)

CJC-1295 with DAC is a GHRH analogue incorporating a Drug Affinity Complex (DAC) — a maleimidopropionic acid (MPA) linker that undergoes selective thiol-Michael addition with the free thiol of Cys-34 of endogenous serum albumin. This covalent thioether bond extends the effective plasma half-life to approximately 8 days via FcRn-mediated albumin recycling, enabling sustained GHRH receptor stimulation across extended experimental timeframes without repeated dosing.

Molecular formula: C165H271N47O46 | Molecular weight: 3647.1 g/mol | CAS: 863288-34-0 | DAC linker: Maleimidopropionic acid | Albumin binding: Covalent thioether at Cys-34 | Purity: greater than or equal to 98% as verified by HPLC | Form: Lyophilised powder | Appearance: White to off-white lyophilised powder | Storage: -20°C desiccated

Cys-34 is the only free (non-disulphide-bonded) cysteine in human serum albumin, making it the primary and selective site for maleimide conjugation. The albumin-peptide conjugate inherits albumin's long half-life through two mechanisms: size-based prevention of glomerular filtration (above 66 kDa) and FcRn-mediated endosomal recycling. This DAC covalent mechanism differs from the non-covalent fatty acid albumin binding used by Semaglutide and Retatrutide.

Counterintuitively, published research (Ionescu and Frohman, JCEM 2006) demonstrated that pulsatile GH secretion persists even with sustained GHRHR stimulation, reflecting hypothalamic somatostatin pacemaker control. For in vitro studies requiring unconjugated peptide, use serum-free media to prevent immediate albumin conjugation. Frequently studied alongside Ipamorelin for dual-receptor GH axis research comparing sustained versus pulsatile stimulation paradigms.

Supplied as a lyophilised powder. Reconstitute with bacteriostatic water. Store at -20°C. For laboratory and analytical research purposes only. Not for human or veterinary use.