CJC-1295 (No DAC)

CJC-1295 without DAC, formally known as Modified GRF 1-29 (Mod GRF 1-29), is a synthetic analogue of the first 29 amino acids of endogenous growth hormone releasing hormone (GHRH). Four targeted amino acid substitutions dramatically improve its metabolic stability compared to native GHRH(1-29): D-Ala at position 2 blocks DPP-IV cleavage; Gln at position 8 prevents asparagine deamidation; Ala at position 15 reduces backbone flexibility; Leu at position 27 prevents methionine oxidation.

Molecular formula: C152H252N44O42 | Molecular weight: 3367.9 g/mol | CAS: 863288-34-0 | Also known as: Modified GRF 1-29 | Amino acids: 29 | Purity: greater than or equal to 98% as verified by HPLC | Form: Lyophilised powder | Appearance: White to off-white lyophilised powder | Storage: -20°C desiccated

CJC-1295 (No DAC) acts at the GHRH receptor (GHRHR), a class B GPCR on pituitary somatotroph cells, activating Gs-coupled cAMP/PKA signalling to stimulate GH gene transcription and exocytosis. Its approximately 30 minute plasma half-life produces discrete pulsatile GH release, mirroring physiological GH secretion dynamics in a way that the sustained elevation from CJC-1295 (With DAC) cannot. This makes it the preferred variant for studying pulse-dependent GH biology and comparing pulsatile versus sustained GHRHR stimulation paradigms.

Published research by Ionescu and Frohman (JCEM, 2006) demonstrated that pulsatile GH secretion persists during continuous GHRHR stimulation due to hypothalamic somatostatin pacemaker control. CJC-1295 (No DAC) is frequently paired with Ipamorelin (GHS-R1a) for complementary dual-receptor GH axis research.

Supplied as a lyophilised powder. Reconstitute with bacteriostatic water. Aliquot to avoid freeze-thaw cycles. Store at -20°C. For laboratory and analytical research purposes only. Not for human or veterinary use.