SLU-PP-322

SLU-PP-332 is a synthetic small molecule and selective pan-agonist of the three oestrogen-related receptors: ERRalpha, ERRbeta, and ERRgamma. These orphan nuclear receptors — named for their structural homology to oestrogen receptors but not activated by oestrogen — are master regulators of mitochondrial biogenesis, oxidative phosphorylation gene expression, and fatty acid oxidation programmes, making SLU-PP-332 a valuable tool compound in metabolic biology, cardiac physiology, and exercise science research.

Molecular formula: C24H18F3N3O2S | Molecular weight: 489.48 g/mol | CAS: 2366993-16-8 | Targets: ERRalpha, ERRbeta, ERRgamma | Drug class: Pan-ERR nuclear receptor agonist | Purity: greater than or equal to 98% as verified by HPLC | Form: Lyophilised powder | Appearance: White to pale yellow crystalline powder | Storage: -20°C desiccated

ERRalpha works in concert with PGC-1alpha — the acknowledged master regulator of mitochondrial biogenesis — driving nuclear-encoded mitochondrial gene expression including OXPHOS subunit genes and fatty acid oxidation enzymes. ERRalpha target gene expression increases substantially following aerobic exercise, positioning SLU-PP-332 as a tool for exercise mimetic research. ERRgamma is the predominant ERR isoform in adult cardiac tissue, regulating the glucose/fatty acid oxidation metabolic switch studied in heart failure models.

Research applications include ERR reporter gene assays (luciferase-based), mitochondrial biogenesis studies (mtDNA copy number, OXPHOS protein expression), fatty acid oxidation assays in C2C12 or primary myocytes, and cardiac metabolism research. Poor aqueous solubility requires DMSO stock preparation; maintain DMSO at or below 0.1% in cell assays.

Supplied as a lyophilised powder. Prepare stock in DMSO. Store at -20°C protected from light. For laboratory and analytical research purposes only. Not for human or veterinary use.